Breast Cancer Treatment Takes Toll on Heart

Radiation therapy has value in breast cancer, but the benefit comes at the price of an increased risk of ischemic heart disease later, researchers reported.

In a population-based case control study, the risk of major coronary events rose after radiation therapy by a mean of 7.4% for every gray (Gy) of exposure to the heart, with no apparent threshold, according to Sarah Darby, PhD, of the Clinical Trial Service Unit in Oxford, England, and colleagues.

The increase in risk was greatest in the first 5 years after radiotherapy but persisted for at least 2 decades, Darby and colleagues reported in the March 14 issue of the New England Journal of Medicine.

In addition, women with preexisting cardiac risk factors had greater absolute increases in risk, the researchers reported.

“Clinicians may wish to consider cardiac dose and cardiac risk factors as well as tumor control when making decisions about the use of radiotherapy for breast cancer,” Darby and colleagues concluded.

The study – among 2,168 breast cancer survivors in Sweden and Denmark — is a wake-up call for physicians, commented Jean-Bernard Durand, MD, of the MD Anderson Cancer Center in Houston.

“We have to be extra vigilant with women, making sure we assess them. We make sure they’re on correct medicines and we make sure they gain all of the benefits from surviving breast cancer,” he told MedPage Today.

Durand noted that in the U.S., women are much less likely than men to receive preventive cardiovascular care; changing that would help to mitigate the risk highlighted by Darby and colleagues.

“Follow their cholesterol, watch for diabetes, manage their blood pressure – all those things can be done to lower their risk of a cardiovascular event,” he said.

The study also highlights the importance of good post-cancer follow-up, he said.

Doctors “have an opportunity to intervene in a young woman and really change the course of her life rather than wait for an event and try to change the course of her life when she’s older,” Durand said.

Radiotherapy for early-stage breast cancer has been shown to reduce both recurrence and death, the researchers noted, but the effect of incidental exposure to the heart has not been clear.

They looked at women with breast cancer who had radiotherapy between 1958 and 2001, including 963 women with major coronary events and 1,205 controls.

Case patients had no recurrence of the breast cancer or incidence of any other cancer before they suffered a major coronary event, defined as myocardial infarction, coronary revascularization, or death from ischemic heart disease.

Controls were matched for country of residence, age at diagnosis, and year of diagnosis, and also had not had a recurrence of their breast cancer or any new malignancy.

Of the major coronary events among women in the study, 44% occurred less than 10 years after the breast cancer diagnosis, 33% occurred in the next decade, and the remaining 23% occurred still later.

The average dose to the heart was 6.6 Gy for women with left breast tumors, 2.9 Gy for those with cancer in the right breast, and 4.9 Gy overall.

While the rate of events rose by 7.4% per Gy of exposure, the rate varied with time — 16.3% in the first 5 years after exposure, 15.5% in the second 5 years, 1.2% in the second decade, and 8.2% in later years.

The only tumor characteristic that significantly affected the risk was location, as women with left breast tumors were more significantly likely to be case patients (P<0.001).

The rate ratio for women who had a history of ischemic heart disease, compared with those who did not, was 6.67 (95% CI from 4.37 to 10.18). Rate ratios were also elevated for women with other circulatory diseases, diabetes, or chronic obstructive pulmonary disease, as well as smokers.

The researchers cautioned that few of the women in the study were under 40, so the results may not apply directly to that age group.

In an accompanying editorial in the journal, Javid Moslehi, MD, of Brigham and Women’s Hospital in Boston commented that the findings may be the “tip of the iceberg.”

“In addition to ischemic cardiac disease,” he wrote, “radiation therapy has been associated with other cardiac conditions, including pericardial disease, peripheral vascular disease, cardiomyopathy, valvular dysfunction, and arrhythmias.

Those diseases were not part of the study, nor were those associated with some forms of chemotherapy, he noted.

One implication for practice, he argued, is that the time to look at cardiovascular issues is at the time of breast cancer diagnosis and before treatment starts.

Source: written by Michael Smith, North American Correspondent, MedPage Today

Published: March/2013
Reviewed by Robert Jasmer, MD; Associate Clinical Professor of Medicine, University of California, San Francisco and Dorothy Caputo, MA, BSN, RN, Nurse Planner
Interview with Dr. Jean-Bernard Durand of the MD Anderson Cancer Center in Houston.

Hair Removal Tips | Don’t try yourself!

Houston Hair Removal Tips: DON’T TRY THIS YOURSELF!!

Did you know that you can visit one of our six clinic locations in Houston for SPA TREATMENTS? Our Houston medical clinics are professionally staffed with people that can help you with your hair removal needs. We have a patented laser hair removal process that is close to painless when professionally done.

Wouldn’t you feel better about an hair removal appointment or really any medical spa treatments at a legitimate medical facility rather than one of these street corner, nail places breeding fungi of all types? We thought so.

Call today and book an appointment for our laser hair removal treatment. During your visit, take a glance at our complete list of medical spa treatments and schedule accordingly. We are here for YOU!

Medical Facial Treatments | Houston

Have you considered a medical facial treatment from the Houston Medical Spa Treatments experts at Doctors Clinic of Houston? What is a medical facial? A medical spa facial treatment is obviously a facial, under the care of a REAL doctor. These facials are handled in a spa-like manner and can consist of exfoliating of the facial skin leaving the skin brighter and younger looking. Deep pore cleansing is necessary for healthy cell rejuvenation, and with a bit of retinol for tightening, you can walk out looking years younger as skin will be more hydrated and nourished looking for a healthier you!

Call Doctors Clinic of Houston today and schedule your medical spa facial – treatments for a healthier you! With 6 locations in the Greater Houston area, one is convenient to your home or work. Call today. You are worth it!

Houston Back Pain Management

Do you suffer from chronic back pain? Have you ever gone jogging and taken a bad step then paid for it for the next week? Most people, at some point in their lives, “tweak” their back and just “wait it out.” Doctors Clinic in Houston has specialists that deal specifically with back pain as well as pain management in general.

Instead of letting back pain, or any other type of pain for that matter, continue for days if not weeks, pick up the phone and call Doctors clinic today. Our pain management specialists can help develop a plan, whether it be medicinal or some type of physical therapy driven plan, and you could be on to a pain free day.

With six locations conveniently located throughout the Greater Houston area (West Memorial, North Freeway, Northwest Freeway, East Freeway, Southwest Freeway), simply choose one and let us help you rid your body of unnecessary pain. Call and schedule today!

This will make it all better

It’s been awhile since we last talked so I am going to bring you up to date on what’s new at Doctors Clinic Houston. For those of you that are feeling dizzy and woozy (not silly) Doctors Clinic Houston has a specialist in to treat Vertigo. and for those of us that are suffering with stress, pain in your arms or legs, high blood pressure, shortness of breath, chest pain, fatigue, high cholesterol, asthma; if you are a smoker or ex-smoker, or noticing swelling in the lower extremities, we are offering Cardio-Pulmonary Test. So come on in or call for direction 713.981.8184.

Well, just maybe it’s not what you’re eating

Have you ever had one of those months when no matter what exercise you did or how many miles you walked, the pounds did not melt away? Well, maybe it’s not only the amount of calories; the carbohydrates, or the fats that are in the foods you are eating, you may need some medical assistance. We have 6 weight loss nurses available to answer your questions so call us today or make an appointment to visit with one of our doctors…and see how jealous your friends will become when you lose the weight.

Where to Take the Kids on Spring Break?

Moms and dads did you get an instant headache when the kids informed you that it’s SPRING BREAK, then asked “where are we going for spring break?” well I have a few suggestions for you… #1. Buy lots of milk and cereal because as you know they are always hungry. #2. Then take your teenagers to a Doctors Clinics Houston facility for a Houston Acne Treatment to treat those pimples; or if you have some special concerns take those concerns and your teenager to a Doctors Clinic Houston Drug Screening, you will sleep better once your kid is clean. After all the healthcare concerns are taken care of, call a taxi and take yourself to one of our Houston Medical Spa Treatments for the very special Houston Medical Facial Treatments. This is Lenny wishing you a safe and HEALTHY Spring Break!

What does Immigration Physicals include at DCH?

At Doctors Clinic Houston complete Houston Immigration Physicals are provided by a qualified medical physician.

Tuberculin (TB) skin test are required if patient is two years of age or older.

Serologic (blood) test for HIV and for syphilis are administered to patients that are 15 years of age and older. Patients under the age of age 15 can be tested for HIV or syphilis if there is reason to suspect the possibility of infection.

Vaccinations: Depending on your age, medical history and current medical condition our physician will determine which of the listed vaccinations are medically appropriate for you:

• Hepatitis A
• Hepatitis B
• Influenza
• Influenza type b (Hib)
• Measles
• Meningococcal
• Mumps
• Pneumococcal
• Pertussis
• Polio
• Rotavirus
• Rubella
• Tetanus and diphtheria toxoids
• Varicella

Occupational Care

Sometimes accidents occur on the job and you might wonder if you should see a doctor just to make sure you are ok. But you dont want to go sit in the emergency room and wait hours to be told to wait even longer, especially if its a minor injury. At Doctors Clinic Houston you do not have to worry about those long waits and department transfers. Our doctors are ready and equiped to take care of your minor injury, referrals and proper prescription care. Each of our six locations have excellent full time Chiropractors on staff and provide in house X-Ray services for our patients. Come to Doctors Clinic Houston and let us take care of you.

Same day doctor’s visits are available at Doctors Clinics Houston

Last week we talked about Patient Education and Chronic Illness Management, I told you about by personal experiences as a patient with Doctors Clinic Houston relating to high blood pressure, diabetes and high cholesterol.

This week lets it’s all about you, as a Walk-in patient. Sometimes it is impossible to make and keep a doctor’s appointment; but you are always welcome to walk-in without an appointment at Doctors Clinic Houston. Same day doctor’s visits are available at Doctors Clinics Houston

We will provide you with prompt care in handling minor emergencies, lacerations, injuries, wound care and infection.

Your schedule is busy so let us keep you healthy.

1 3 4 5 6